{"Abbreviation":["LSD","LSD-25"],"Absorption, Distribution and Excretion":"Rapidly absorbed.","Adverse Effects":"Adverse effects are extremely subjective, with significant variability and unpredictability. One patient may experience a positive effect filled with bright hallucinations, sights, and sensations, increased awareness owing to mind expansion, and marked euphoria. The positive spectrum of effects is colloquially called a \"good trip.\" Another patient may experience the total opposite with an experience filled with increased anxiety becoming panic, fear, depression, despair, and disappointment. The negative spectrum is colloquially called a \"bad trip.\" One patient can experience both the positive and negative spectrum at different times of use.","Aliases":["Lysergide","Lysergic acid diethylamide","Lsd","N,N-Diethyllysergamide","Lysergsaeurediaethylamid","N,N-Diethyl-D-lysergamide","Lysergaure diethylamid","LSD-25","LSD 25","Lisergide","Lysergidum","N,N-Diethyl-(+)-Lysergamide","lysergic Acid diethylamide","lisergida","Diethylamid kyseliny lysergove","CHEBI:6605","Dtxcid003231","Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8β)-","(8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide","(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide","(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo(7.6.1.0^(2,7).0^(12,16))hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide","(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo(4,3-fg)quinoline-9-carboxamide","Acid Diethylamide, Lysergic","Diethylamide, Lysergic Acid","(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo(7.6.1.02,7.012,16)hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide","200-033-2","Delysid","Lysergamid","LSD","Lysergic acid diethylamide-25","Lysergsauerediaethylamid","Lysergamide, N,N-diethyl-","HSDB 3920","Lysergsaeurediethylamid","[3H]-LSD","Chembl263881","Cubes","Pearly gates","Heavenly Blue","Royal blue","Ncgc00168265-01","Ncgc00168265-02","Clearlight","Ubergluben","Barrels","Bartman","Cupcakes","Greenies","Lisergido","Microdots","Spoonies","Sunshine","Trippers","Yellows","Beast","Chembl463207","Chief","Domes","Fifty","Flats","Owsley","Scapes","Wedges","Chocolate Chips","Orange Mushroom","Orange Sunshine","Purple Microdot","Gelatin Chips","Mellow Yellow","Orange Wedges","Bart Simpson","Blotter Acid","Contact Lens","(8α)-N,N-Diethyl-6-Methyl-9,10-Didehydroergoline-8-Carboxamide","Purple Haze","White Light","Window Pane","Blue Cheer","Brown Dots","Cherry Top","Mean Green","Paper Acid","Sugar Lump","Blue Acid","Blue Mist","Blue Star","Strawberry Fields","The Hawk","Cas-50-37-3","California Sunshine","Big F","Einecs 200-033-2","Brn 0094179","Hawk","Haze","Lids","Lucy in the Sky with Diamonds","Instant Zen","DEA No. 7315","Wedding Bells Acid","7LD","[N-methyl-3H]LSD","LYSERGIDE","LSD,l-","9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-β-carboxamide","Ergoline-8β-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-","GTPL17","Indolo[4,3-fg]quinoline, ergoline-8-carboxamide deriv.","4-25-00-00939","Schembl113755","Niosh/ke4200000","Schembl29349465","BDBM21342","LSD,(+)","9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide","Lysergic acid diethylamide, l-isomer","Tox21_112872","Tox21_113508","Bdbm50241702","Ergoline-8-β-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-","Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8b)-","Pdsp1_001431","Pdsp1_001540","Pdsp2_001415","Pdsp2_001524","Lysergic acid diethylamide tartrate ci","DB04829","US20240166618, Compound LSD","KE42000000","NS00000052","C07542","LSD (Lysergic Acid Diethylamide) 0.025 mg/ml in Acetonitrile","LSD (Lysergic Acid Diethylamide) 1.0 mg/ml in Acetonitrile","N,N-Diethyl-6-methyl-9,10-didehydroergoline-8β-carboxamide","(8β)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide","9,10-Didehydro-n,n-diethyl-6-methyl-ergoline-8b-carboxamide","LSD (d-Lysergic acid N,N-diethylamide), 0.1mg/ml in Acetonitrile","LSD (d-Lysergic acid N,N-diethylamide), 1mg/ml in Acetonitrile","Ergoline-8-β-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (-)-","Ergoline-8b-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-","(8β)-9,10-Didehydro-n,n-diethyl-6-methylergoline-8-carboxamide","Ergoline-8-carboxamide, 9,10-didehydro-n,n-diethyl-6-methyl-, (5β, 8β)-","(6aR,9R)-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide"],"Biological Half-Life":"3 hours","CAS":"50-37-3","ChemicalClasses":["lysergamide"],"Chirality":"absolute","Classes":["Psychedelic"],"Color/Form":"Pointed prisms from benzene","DBI-IGS":["LSD","LSD"],"DTXSID":"RefChem:5968","Decomposition":"When heated to decomposition it emits toxic fumes of /nitrogen oxides/.","Dosing Info":[{"Method":"Sublingual","Tiers":{"Common":{"Entries":4,"Lower":0.2,"Percentage":50,"Unit":"mg","Upper":0.3},"Extreme":{"Entries":1,"Lower":0.5,"Percentage":12.5,"Unit":"mg","Upper":0.5},"Heavy":{"Entries":1,"Lower":0.3,"Percentage":12.5,"Unit":"mg","Upper":0.5},"Light":{"Entries":2,"Lower":0.2,"Percentage":25,"Unit":"mg","Upper":0.2},"Strong":{"Entries":0,"Lower":0.3,"Percentage":0,"Unit":"mg","Upper":0.3}}},{"Method":"Oral","Tiers":{"Common":{"Entries":7,"Lower":0.2,"Percentage":30.4,"Unit":"mg","Upper":0.3},"Extreme":{"Entries":2,"Lower":0.8,"Percentage":8.7,"Unit":"mg","Upper":0.8},"Heavy":{"Entries":4,"Lower":0.6,"Percentage":17.4,"Unit":"mg","Upper":0.8},"Light":{"Entries":6,"Lower":0.2,"Percentage":26.1,"Unit":"mg","Upper":0.2},"Strong":{"Entries":4,"Lower":0.3,"Percentage":17.4,"Unit":"mg","Upper":0.6}}}],"Drug Indication":"Lysergic acid diethylamide (LSD) is a classical hallucinogen originally synthesized by Albert Hoffman. He accidentally concocted the drug while making experimental substances from ergots to create circulatory and respiratory stimulants. The most pronounced effect on the animals allowed him to create a model for psychosis and study the induced temporary psychotic-like states. During the psychotic state, he also noted permitted recall and produced improved insight.","DurationOfAction":"Oral administration|Oral: 7 – 12 (range 4 – 22) hoursIntramuscular injection, Intravenous injection, Intrathecal injection: 8 – 10 hours","EliminationHalfLife":"3.6 hours","Erowid Experience Reports":[{"Author":"GKS","Id":5451,"Title":"Military LSD Testing"},{"Author":"Ssomeone Else","Id":19100,"Title":"5 Hits?"},{"Author":"Ciccione Youth","Id":19958,"Title":"All But Nothing"},{"Author":"woe","Id":35934,"Title":"I Wonder What Else I Can't Feel in Life"},{"Author":"T","Id":41899,"Title":"The Effects Never Came"},{"Author":"Adina","Id":47759,"Title":"Unaffected on Antidepressants"},{"Author":"Craig M","Id":67200,"Title":"No Trip with Subutex"},{"Author":"Dr. Rhodes","Id":84153,"Title":"Two Months Wasn't Enough"},{"Author":"Gwern.net","Id":101638,"Title":"LSD Microdosing RCT"},{"Author":"bradkehlerits me","Id":106250,"Title":"AcidAlbizia. Where's My Chinese Happiness"},{"Author":"Sktbx","Id":472,"Title":"LSD Less Effective For Me"},{"Author":"Del Neshom","Id":819,"Title":"My experiences with LSD"},{"Author":"Misphunkshinz","Id":1384,"Title":"Out of Body LSD"},{"Author":"Anonymous","Id":1990,"Title":"A Sudden Respect for the Complexity of Things"},{"Author":"Murple","Id":2367,"Title":"Mind Painting"},{"Author":"Dark Star","Id":2756,"Title":"An LSD Let Down"},{"Author":"Crazy S","Id":3108,"Title":"Beyond What is Real"},{"Author":"Smiling Sound","Id":3690,"Title":"A Psychedelic Way of Life"},{"Author":"TheOtherSide","Id":4581,"Title":"Visual Administration"},{"Author":"Satan Himself","Id":5331,"Title":"LSD \u0026 Dreaming"},{"Author":"Penguin Butler","Id":6853,"Title":"External to My Own Self"},{"Author":"Dr. Copious","Id":7960,"Title":"It Took Forever"},{"Author":"The Correspondent","Id":12304,"Title":"I Can Understand!"},{"Author":"Confused","Id":14717,"Title":"HPPD and Other Drugs"},{"Author":"Samanthe","Id":16655,"Title":"Microdoses: Consistent Desired Results"},{"Author":"Floyd F","Id":18486,"Title":"Intelligence Enhancement, Without Empathy"}],"Esters":[],"European Community (EC) Number":"200-033-2","Formating":[],"Health Effects":"Chronic effects of LSD toxicity include flashbacks, psychosis, and exacerbation of latent mental disorders, particularly schizophrenia. Overdosage can result in “bad trips” that are characterized by intense anxiety, combativeness, confusion, and panic attacks. LSD is not considered to be addictive, and withdrawal syndrome are absent. Because of its relatively high therapeutic index, no deaths have been directly attributed to LSD use alone. (A2915, L1925)","HeavyAtomCount":24,"IUPACName":"(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide","InChI":"InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1","InChIKey":"VAYOSLLFUXYJDT-RDTXWAMCSA-N","Interactions":"... This study aims to determine if parenteral injections of the hallucinogens LSD, d,l-2,5-dimethoxy-4-methylamphetamine, and 5-methoxy-dimethyltryptamine /to rabbits/ elicit the 5-HT(2A)-mediated behavior of head bobs and whether intrahippocampal injections of LSD would produce head bobs and enhance trace eyeblink conditioning. LSD was infused into the dorsal hippocampus just prior to each of eight conditioning sessions. One day after the last infusion of LSD,(+/-)-1(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)  was infused into the hippocampus to determine whether there had been a desensitization of the 5-HT(2A) receptor as measured by a decrease in DOI-elicited head bobs. Acute parenteral or intrahippocampal LSD elicited a 5-HT(2A) but not a 5-HT(2C)-mediated behavior, and chronic administration enhanced conditioned responding relative to vehicle controls. Rabbits that had been chronically infused with 3 or 10 nM per side of LSD during Pavlovian conditioning and then infused with DOI demonstrated a smaller increase in head bobs relative to controls. LSD produced its enhancement of Pavlovian conditioning through an effect on 5-HT(2A) receptors located in the dorsal hippocampus. The slight, short-lived enhancement of learning produced by LSD appears to be due to the development of desensitization of the 5-HT(2A) receptor within the hippocampus as a result of repeated administration of its agonist (LSD).","MeSH Headers":[{"Id":"M0012833","Link":"https://id.nlm.nih.gov/mesh/M0012833.html","Name":"Lysergic Acid Diethylamide","Ref":66},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":68},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":90},{"Id":"M0009763","Link":"https://id.nlm.nih.gov/mesh/M0009763.html","Name":"Hallucinogens","Ref":91},{"Id":"M0019685","Link":"https://id.nlm.nih.gov/mesh/M0019685.html","Name":"Serotonin Antagonists","Ref":92},{"Id":"M0026371","Link":"https://id.nlm.nih.gov/mesh/M0026371.html","Name":"Serotonin Receptor Agonists","Ref":93}],"MeSH Pharmacological Classification":[{"Id":"M0009763","Link":"https://id.nlm.nih.gov/mesh/M0009763.html","Name":"Hallucinogen","Ref":91},{"Id":"M0019685","Link":"https://id.nlm.nih.gov/mesh/M0019685.html","Name":"Serotonin Antagonist","Ref":92},{"Id":"M0026371","Link":"https://id.nlm.nih.gov/mesh/M0026371.html","Name":"Serotonin Receptor Agonist","Ref":93}],"Mechanism of Action":"The goal of the present study was to better delineate the mechanisms of action of the prototypical hallucinogen LSD. LSD (0.03, 0.1 and 0.3 mg/kg, s.c.) produced locomotor hyperactivity, disruption of /prepulse inhibition (PPI)/ and a number of behaviors indicative of 5-HT activation such as wet-dog shakes, back muscle contractions and forepaw treading. These various behavioral effects of LSD were studied in both Sprague-Dawley and Wistar rats, although with the exception of back muscle contractions which were more prominent in Sprague-Dawley rats, no major strain differences were detected. The PPI disruption induced by LSD (0.1 mg/kg) in Sprague-Dawley rats was completely reversed by pretreatment with the selective 5-HT(2A) antagonist MDL 100907 (0.5 and 1 mg/kg, s.c.). In contrast, pretreatment with antagonists at 5-HT(2C), (SB 242084 (0.5 mg/kg, i.p.)); 5-HT(2B/2C) (SDZ SER 082 (1 mg/kg, s.c.)); 5-HT(1A), ((+)-WAY 100135 (1 and 20 mg/kg, s.c.)) and 5-HT(6) receptors, (RO 04-6790 (30 mg/kg, i.p.)), all failed to influence LSD-induced disruption of PPI. The dopamine DA(2like) receptor antagonist, haloperidol (0.1 and 0.2 mg/kg, s.c.), was without effect against an LSD-induced disruption of PPI. Finally, selective blockade of 5-HT(2A) but not 5-HT(2C) receptors completely abolished the locomotor hyperactivity induced by LSD. These findings provide empirical evidence to support the view that the hallucinogenic effects of LSD are mediated by a direct agonist effect at 5-HT(2A) receptors.","Melting Point":"176 to 185 °F (NTP, 1992)","Metabolism/Metabolites":"Hepatic.","MolecularFormula":"C\u003csub\u003e20\u003c/sub\u003eH\u003csub\u003e25\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003eO","MolecularWeight":"323.4 g/mol","Non-Human Toxicity Values":"LD50 Guinea pig sc 16 mg/kg","Odor":"Odorless","Opticalactivity":"( + )","Physical Description":"Prismatic crystals (from benzene). Tasteless and odorless. A hallucinogen.","PubChemId":5761,"Record Description":["Wikipedia|TiHKAL|Tryptamines"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"5968","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/LSD","Name":"Lysergic acid diethylamide","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q23118","Name":"Lysergic acid diethylamide","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB04829","Name":"Lysergic acid diethylamide","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5761","Name":"Lysergic acid diethylamide","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=50-37-3","Name":"Lysergic acid diethylamide","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07542","Name":"Lysergic acid diethylamide","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/8NA5SWF92O","Name":"Lysergic acid diethylamide","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023231","Name":"Lysergic acid diethylamide","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5761, Lysergide. Accessed May 16, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5761\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5761\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Lysergic acid diethylamide. UNII: 8NA5SWF92O. Global Substance Registration System. Accessed May 16, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/8NA5SWF92O\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/8NA5SWF92O\u003c/a\u003e"],"Reported Fatal Dose":"LSD has not been known to cause death on its own. 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4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.768h.578zM14.912 117.464h-.619v-2.286h-2.512v2.286h-.613v-4.899h.613v2.071h2.512v-2.071h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#3050f8\" d=\"m67.048 20.052-.001-5.695M70.203 25.721l5.024 2.899M63.896 25.723l-5.022 2.901M67.062 65.769l-.003-5.694M20.748 115.366l5.911.623M20.748 115.366l5.911.623M16.603 111.195l-1.178-5.544M16.603 111.195l-1.178-5.544M70.217 71.438l5.025 2.897\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Taste":"Tasteless","Therapeutic Uses":"Hallucinogens; Serotonin Agonists; Serotonin Antagonists","Title":"Lysergic acid diethylamide","Toxicity Data":"Estimates for the lethal dosage (LD50) of LSD range from 200 ug/kg to more than 1 mg/kg of human body mass, though most sources report that there are no known human cases of such an overdose.","Treatment":"Adverse effects of psychotropics are often treated with fast-acting benzodiazepines like diazepam or triazolam that have calming and antianxiety effects but do not directly affect the specific actions of psychotropics. Theoretically, specific 5-HT2A receptor antagonists, which most commonly means atypical antipsychotics (quetiapine, olanzapine, risperidone, etc.) or other 5-HT2A antagonist such as trazodone  or mirtazapine, would be direct antidotes, although some anecdotal reports claim otherwise. (A308, L1925)","UNII":"8NA5SWF92O","Wikidata":"Q23118","Wikipedia":"LSD","XLogP":3}
